Cleavage of both LexA and UmuD is stimulated by a protein called RecA, which is activated by single-stranded DNA resulting from DNA damage.

#Id: 3361

#Unit 3. Fundamental Processes

#Id: 3363

#Unit 3. Fundamental Processes

The two chromophores in E. coli photolyase (Mr 54,000), N5 N10-methenyltetrahydrofolylpolyglutamate (MTHF polyGlu) and FADH , perform complementary functions.

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#Unit 3. Fundamental Processes

In reversal, MTHF polyGlu functions as a photoantenna to absorb blue-light photons.

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#Unit 3. Fundamental Processes

In E. coli, DNA Pol IV (DinB) or DNA Pol V (a complex of the proteins UmuC and UmuD0 ) performs translesion synthesis. 

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#Unit 3. Fundamental Processes

DinB and UmuC are members of a distinct family of DNA polymerases found in many organisms known as the Y family of DNA polymerases. There are five translesion polymerases known in humans, four of which belong to the Y family.

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#Unit 3. Fundamental Processes