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TLS Online TPP Program

#Id: 3419

Ku70 and Ku80 are the most fundamental components of NHEJ. They constitute a heterodimer that binds to the DNA ends and recruits DNA-PKcs, which is a protein kinase

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 10502

#Unit 4. Cell Communication and Cell Signaling

Four genes play an essential role in controlling apoptosis during C. elegans development: 
ced-3, ced-4, ced-9, and egl-1
TLS Online TPP Program

#Id: 10503

#Unit 4. Cell Communication and Cell Signaling

In C. elegans BH3-only protein EGL-1 initiate apoptosis by binding to and inactivating CED-9
TLS Online TPP Program

#Id: 10504

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 protein = C. elegans CED-9 protein
(23% identical in aa sequence)
TLS Online TPP Program

#Id: 10505

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins act as regulators that suppress the apoptotic pathway
TLS Online TPP Program

#Id: 10506

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins contain a single TM domain and are localized to the outer mitochondrial membrane
TLS Online TPP Program

#Id: 10507

#Unit 4. Cell Communication and Cell Signaling

CED-9 protein, forms a complex with a dimer of the CED-4 protein, preventing the CED-4 protein from activating the CED-3 protease