Exons are usually short, typically encoding fewer than 100 amino acids

Exon sequences are conserved by the negative selection of individuals in which the sequences have changed.

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#Unit 5. Developmental Biology

B cell is type of lymphocyte. B cell synthesized and maturation in Bone marrow.

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#Unit 5. Developmental Biology

Stages in hematopoiesis

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#Unit 5. Developmental Biology

B cell properties 

They are APCs

They can express MHC2

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Part of Adaptive immunity 

B cell convert into plasma cell

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#Unit 5. Developmental Biology

Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7 (CD80/86)

ICAM-1

MHC-1 and 2

CD 22

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#Unit 5. Developmental Biology

Formation of mature B-cell

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#Unit 5. Developmental Biology

Progress through their developmental program