RFLPs and SNPs can be the basis for linkage maps and are useful for establishing parent–offspring relationships.

#Id: 324

#Unit 1. Structure and Function of Biomolecules

#Id: 326

#Unit 1. Structure and Function of Biomolecules

When blood glucose rises above 5 mM, hexokinase IV activity increases, but hexokinase I is already operating near Vmax and cannot respond to an increase in glucose concentration. 

#Id: 327

#Unit 1. Structure and Function of Biomolecules

Hexokinase IV is subject to inhibition by the reversible binding of a regulatory protein specific to liver

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#Unit 1. Structure and Function of Biomolecules

#Id: 333

#Unit 1. Structure and Function of Biomolecules

Fructose 2,6-bisphosphate binds to its allosteric site on PFK-1, it increases the enzyme’s affinity for its substrate fructose 6-phosphate and reduces its affinity for the allosteric inhibitors ATP and citrate

#Id: 335

#Unit 1. Structure and Function of Biomolecules

Glucagon lowers the cellular level of fructose 2,6 bisphosphate, inhibiting glycolysis and stimulating gluconeogenesis.