There are two class of AATS.
1.Class I – that transfer amino acid at 2’ OH and then 3’ OH &
2. Class II – that directly transfer the amino acid to 3’ OH

TLS Online TPP Program

#Id: 10423

#Unit 4. Cell Communication and Cell Signaling

Tumor cells secrete a protein plasminogen activator that converts the serum protein plasminogen to the active protease plasmin.

TLS Online TPP Program

#Id: 10424

#Unit 4. Cell Communication and Cell Signaling

Noncoding RNAs, especially microRNAs, play a critical role in tumorigenesis:

Let-7 miRNAs

miR-15-a 

miR-16-1

miR-21

TLS Online TPP Program

#Id: 10425

#Unit 4. Cell Communication and Cell Signaling

Let-7 miRNAs repress the translation of Ras mRNA and also targets MYC

TLS Online TPP Program

#Id: 10426

#Unit 4. Cell Communication and Cell Signaling

miR-15-a and miR-16-1, control the proliferation of 

B cells

TLS Online TPP Program

#Id: 10427

#Unit 4. Cell Communication and Cell Signaling

miR-21 targets PTEN phosphatase

TLS Online TPP Program

#Id: 10428

#Unit 4. Cell Communication and Cell Signaling

DNA methylation occurs at cytosines of CpG islands, leads to repression of the promoters. DNA hypermethylation & DNA hypomethylation is also a hallmark of cancer.