Nurturing Life Sciences
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#Unit 2. Cellular Organization
Acetylation neutralizes the positive charge of lysine so disrupts DNA Histone interactions.
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lysine methylation retains the positive charge, and lysine can be mono-, di-, or trimethylated.
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Histone codes are specific and conserved residues that undergoes to modification and changes expression of chromatin.
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Histone tail modifications
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Bromodomains recognize acetylated lysine.
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The chromodomain is a common protein motif of 60 amino acid that recognizes methylated lysine and Arg.