Nurturing Life Sciences
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In any particular cell, most genes are expressed at a low level
Only a small number of genes, whose products are specialized for the cell type, are highly expressed.
mRNAs expressed at low levels overlap extensively when different cell types are compared.
The abundantly expressed mRNAs are usually specific for the cell type.
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#Unit 3. Fundamental Processes
In the Pyrophosphorolytic editing, the enzyme uses its active site, in a simple back-reaction, to catalyze the removal of an incorrectly inserted ribonucleotide, by reincorporation of PPi.
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Hydrolytic editing, is the polymerase backtracks by one or more nucleotides and cleaves the RNA product, removing the error-containing sequence.
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Hydrolytic editing is stimulated by Gre factors, which both enhance hydrolytic editing function and serve as elongation stimulating factors.
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The Nus proteins—joins polymerase in the elongation phase and promotes.
#Id: 2411
Both polymerase removal and repair enzyme recruitment are performed by a single protein called TRCF.
#Id: 2412
TRCF has an ATPase activity.