Nurturing Life Sciences
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#Unit 3. Fundamental Processes
Extensive shortening of telomeres is recognized by the cell as a double-strand break and consequently triggers cell cycle arrest and apoptosis.
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In mammals, six telomeric proteins (TRF1, TRF2, Rap1, TIN2, TPP1, and POT1) comprise a complex called shelterin
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Duplex telomeric DNA interactions of TRF1 and TRF2 and the binding of POT1 to the single-stranded TTAGGG repeats.
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Shelterin functions to protect telomeres from DNA damage repair pathways and to regulate telomere length control by telomerase
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For the synthesis of telomere, Only dGTP and dTTP are needed for the activity.