TLS Online TPP Program

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H3 and H4 histones first form heterodimers that then come together to form a tetramer with two molecules each of H3 and H4. While H2A and H2B form heterodimers in solution but not tetramers. This assembly without DNA called Histone-only Intermediates 

#Unit 2. Cellular Organization #Structure & Assembly of Histones #Part B Pointers