Nurturing Life Sciences
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#Unit 5. Developmental Biology
During cleavage, β-catenin enters the nuclei and binds with Tcf3 to form a transcription factor that activates genes encoding proteins Siamois and Twin.
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Siamois and Twin interact in the organizer with the Smad2 transcription factor activated by vegetal TGF-β family members (Nodal-related proteins, Vg1, activin)
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Twin and Siamois encode homeodomain transcription factors and are expressed in the organizer
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High β-catenin + Nodal related high + Veg T, Vg1 = Organizer
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Nodal related low + Veg T, Vg1 = Ventral mesoderm
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The “default fate” of the ectoderm is to become neural tissue