H2AZ variant has 60% sequence identity with canonical H2A and involved in gene activation, heterochromatin–euchromatin boundary formation, cell-cycle progression.

TLS Online TPP Program

#Id: 4756

#Unit 5. Developmental Biology

The SKN-1 protein is a maternally expressed transcription factor that controls the fate of the P1 blastomere(P1🡪EMS 🡪MS), that generates the posterior pharynx.

TLS Online TPP Program

#Id: 4757

#Unit 5. Developmental Biology

Embryos from homozygous skn-1-deficient mothers lack both pharyngeal mesoderm & endoderm derivatives of EMS.

TLS Online TPP Program

#Id: 4758

#Unit 5. Developmental Biology

skn-1-deficient embryos make extra hypodermal (skin) & body wall tissue.

TLS Online TPP Program

#Id: 4759

#Unit 5. Developmental Biology

PAL-1 activity is needed for the normal development of the somatic (but not the germline) descendants of the P2 blastomere, specifies muscle production.

TLS Online TPP Program

#Id: 4760

#Unit 5. Developmental Biology

Embryos lacking PAL-1 have no somatic cell types derived from the C and D stem cells.

TLS Online TPP Program

#Id: 4761

#Unit 5. Developmental Biology

PAL-1 is regulated by the MEX-3 protein, an RNA binding protein that inhibit the translation of pal-1 mRNA.