Scanned-probe microscopy is of two types:

Scanning tunneling microscopy

Atomic force microscopy

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Major U2-type or GU-AG introns

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#Unit 3. Fundamental Processes

Minor U12-type with GU-AG introns (hybrid type)

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Splice sites are directional in nature. 5’ splice site -the left, or donor, site and the 3’ splice site - right, or acceptor, site

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#Unit 3. Fundamental Processes

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Lariat formation is characterize by 2’-5’ phosphodiester bond Prp8, a large scaffold protein that directly contacts both the 5’ and 3’ splice sites within the spliceosome.

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Prp5 is critical for U2 binding

Brr2 facilitates U1 and U4 release

Prp2 is responsible for the activation of the spliceosome Prp22 helps the release of the mature mRNA from the spliceosome