Nurturing Life Sciences
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#Unit 2. Cellular Organization
Most H2A variants contain alternative C-termini, except H2ABbd, which contains a distinct N terminus.
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SpH2B has a long N-terminus and functions in Chromatin packaging
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In yeast, centromeric nucleosomes consist of Cse4, H4, and a nonhistone protein Scm3, in place of H2A-H2B dimers.
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In Drosophila, the centromeric chromatin appears to consist of “hemisomes” containing one copy each of CenH3, H4, H2A, and H2B.
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Histone H3.1 is replicative histone.
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H3.3 is expressed throughout the cell cycle, in contrast to most histones that are expressed during S phase during replication.