Gene Interaction with Epistasis

The effect of gene interaction is that one gene masks (hides) the effect of another gene at a different locus.

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#Unit 5. Developmental Biology

C. elegans oocyte use the “partitioning-defective,” or PAR proteins, in establishing cell polarity. 

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#Unit 5. Developmental Biology

Cortical cytoplasm contains PAR-3, PAR-6 & PKC-3 Internal cytoplasm contains PAR-2 and PAR-1

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#Unit 5. Developmental Biology

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#Unit 5. Developmental Biology

PKC-3 restricts PAR-1 and PAR-2 to the internal cytoplasm by phosphorylating them.

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#Unit 5. Developmental Biology

Sperm microtubules contacts the cortical cytoplasm and initiates cytoplasmic movements that push the male pronucleus to the nearest end of the oblong oocyte.

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#Unit 5. Developmental Biology

Sperm microtubules protect PAR-2 protein from phosphorylation, allowing it to enter the cortex along with its binding partner, PAR-1.