The POP-1 encodes the TCF protein that binds β-catenin & blocks the pathway to the E fate by inhibiting endodermal transcription factors (END-1) in the prospective MS cell

TLS Online TPP Program

#Id: 10463

#Unit 4. Cell Communication and Cell Signaling

MYC-MAX dimers regulate genes that control proliferation, such as cyclins.

TLS Online TPP Program

#Id: 10464

#Unit 4. Cell Communication and Cell Signaling

MAD and MNT work with the SIN3 co-repressor protein to bring in histone deacetylases that help to block transcription

TLS Online TPP Program

#Id: 10465

#Unit 4. Cell Communication and Cell Signaling

A classic inherited cancer syndrome is retinoblastoma, which is caused by loss of function of RB.

TLS Online TPP Program

#Id: 10466

#Unit 4. Cell Communication and Cell Signaling

Children with hereditary (familial) retinoblastoma inherit one defective copy of the RB gene 

(sometimes seen as a small deletion on one of the two copies of chromosome 13)

TLS Online TPP Program

#Id: 10467

#Unit 4. Cell Communication and Cell Signaling

Sporadic retinoblastoma, inherit two normal RB alleles, each of which has undergone a LOF somatic mutation in a single retinal cell

TLS Online TPP Program

#Id: 10468

#Unit 4. Cell Communication and Cell Signaling

Subsequent loss or inactivation of the remaining normal allele in a somatic cell, known as loss of heterozygosity causes cancer to develop.