Anticlotting mechanisms  The tendency of blood to clot is balanced in vivo by reactions that prevent clotting inside the blood vessels, break down any clots that 

do form, or both.

TLS Online TPP Program

#Id: 1547

#Unit 2. Cellular Organization

Taxol, 

A plant alkaloid from the Pacific yew tree

Binds microtubules and stabilizes them against depolymerization

TLS Online TPP Program

#Id: 1548

#Unit 2. Cellular Organization

Nocodazole and colchicine

TLS Online TPP Program

#Id: 1549

#Unit 2. Cellular Organization

Two main families of motor proteins mediate transport along microtubules:

Kinesins 

Dyneins

TLS Online TPP Program

#Id: 1550

#Unit 2. Cellular Organization

Kinesin-1 powers anterograde transport of vesicles down axons toward the (+) ends of microtubules.

TLS Online TPP Program

#Id: 1551

#Unit 2. Cellular Organization

Kinesin-1  (similar to myosin II)

Head domain at the N-terminus of the heavy chain  

Stalk domain forms a long coiled-coil

Tail domain at C-terminus that attaches to cargo

TLS Online TPP Program

#Id: 1552

#Unit 2. Cellular Organization

Kinesin-5 forms tetramers, assembled in a bipolar configuration to interact with two antiparallel microtubules and move toward the (+) ends.