Plasmin is formed from its inactive precursor, plasminogen, by the action of thrombin and tissue-type plasminogen activator (t-PA).

TLS Online TPP Program

#Id: 3131

#Unit 3. Fundamental Processes

Initiation may require full methylation of the Dam target sites in the origin, or it may be inhibited by hemimethylation of these sites.

TLS Online TPP Program

#Id: 3132

#Unit 3. Fundamental Processes

The GATC sites at the origin remain hemimethylated for -13 minutes after replication.

TLS Online TPP Program

#Id: 3133

#Unit 3. Fundamental Processes

Initiation at oriC requires the sequential assembly of a large protein complex on the membrane.

TLS Online TPP Program

#Id: 3134

#Unit 3. Fundamental Processes

The ability of a plasmid relying upon oriC to replicate in dam- E. coli depends on its state  of methylation.

TLS Online TPP Program

#Id: 3159

#Unit 3. Fundamental Processes

 Eukaryotic cells have many DNA polymerases. The replication enzymes operate with high fidelity. Except  for the β enzyme, the repair enzymes all have low fidelity.

TLS Online TPP Program

#Id: 3160

#Unit 3. Fundamental Processes

Replication enzymes have large structures, with separate subunits for different activities. Repair enzymes have much simpler structures.