Genes that share a common ancestry have similar organizations with conservation of the positions (of at least some) of the introns.

TLS Online TPP Program

#Id: 10490

#Unit 4. Cell Communication and Cell Signaling

perforins punch holes in the endocytic vesicle membrane, allowing granzymes to enter the cytoplasm

TLS Online TPP Program

#Id: 10491

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10492

#Unit 4. Cell Communication and Cell Signaling

Granzymes are serine proteases and cleave and activate

apoptotic molecules within the target cells, causing programmed cell death.

TLS Online TPP Program

#Id: 10493

#Unit 4. Cell Communication and Cell Signaling

Some Cytotoxic T cells express on their surface FasL, a natural ligand molecule related to TNF

TLS Online TPP Program

#Id: 10494

#Unit 4. Cell Communication and Cell Signaling

FasL on the cytotoxic T cell binds to its receptor, the Fas protein on the tumor cells, an apoptotic signaling pathway in the tumor cells becomes activated, which leads to tumor cell death.

TLS Online TPP Program

#Id: 10495

#Unit 4. Cell Communication and Cell Signaling

Apoptosis 

genetically regulated process

Cell destroys itself (programmed cell death)

marked by the breakdown of cell components