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TLS Online TPP Program

#Id: 5289

βγ subunit of a G protein, open a special set of K + channels. The resulting IKAch slows the depolarizing effect of Ih .

#Unit 7. System Physiology – Animal #Cardiovascular System #Part B Pointers
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TLS Online TPP Program

#Id: 1557

#Unit 4. Cell Communication and Cell Signaling

Wnt = wingless + integrated
TLS Online TPP Program

#Id: 1558

#Unit 4. Cell Communication and Cell Signaling

Wnt proteins are essential for- 
Brain development
Limb patterning
Organogenesis
Formation of osteoblasts
TLS Online TPP Program

#Id: 1559

#Unit 4. Cell Communication and Cell Signaling

Wnt proteins are synthesized in the ER & modified by the addition of lipids (palmitic and palmitoleic acid).
 
TLS Online TPP Program

#Id: 1560

#Unit 4. Cell Communication and Cell Signaling

Lipid modifications of Wnt are catalyzed by the O-acetyltransferase Porcupine.
TLS Online TPP Program

#Id: 1561

#Unit 4. Cell Communication and Cell Signaling

Principal signaling receptor for Wnt proteins is Frizzled (Fz), which contains seven transmembrane α helices.
TLS Online TPP Program

#Id: 1562

#Unit 4. Cell Communication and Cell Signaling

Lipidated Wnt can bind to Frizzled receptor because lipids are essential for Wnt to bind to Frizzled.