Isovolumetric Ventricular Contraction

Initiates contraction of the ventricles

Intraventricular pressure rises sharply as the myocardium presses on the blood in the ventricle

TLS Online TPP Program

#Id: 8630

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8631

#Unit 2. Cellular Organization

APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module

TLS Online TPP Program

#Id: 8632

#Unit 2. Cellular Organization

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]

TLS Online TPP Program

#Id: 8633

#Unit 2. Cellular Organization

Mutating or deleting the destruction box in mitotic cyclins prevented their ubiquitination and blocked cells from exiting mitosis.

TLS Online TPP Program

#Id: 8634

#Unit 2. Cellular Organization

At the metaphase to anaphase transition, APC/C bound to Cdc20 targets cyclins A /B and securin for degradation.

TLS Online TPP Program

#Id: 8635

#Unit 2. Cellular Organization

During late anaphase, telophase and G1, APC/C bound to Cdh1 targets B type cyclins and geminin for degradation.