Leaky Expression

In repressed state, an occasional transcript gets made. This happens because every so often, RNA polymerase will manage to bind the promoter in place of the Lac repressor. This leakiness encode meager level of Z, Y and A.

TLS Online TPP Program

#Id: 8518

#Unit 2. Cellular Organization

Defects in LIS1 

Miller-Dieker lissencephaly

means “smooth brain”

TLS Online TPP Program

#Id: 8519

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8520

#Unit 2. Cellular Organization

Post-translational modifications of tubulin:

Lysine acetylation

Detyrosylation

Polyglutamylation

Polyglycylation

TLS Online TPP Program

#Id: 8521

#Unit 2. Cellular Organization

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.

TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 

ε-amino group of a specific lysine of α-tubulin

Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)

TLS Online TPP Program

#Id: 8523

#Unit 2. Cellular Organization