ACTH (corticotropin) 

controls the secretion of cortisol by the activation of adenylyl cyclase via Galpha s.

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#Id: 8472

#Unit 1. Molecules and their Interaction Relevant to Biology

Poly(Gly) chains also adopt secondary conformations. 

In the solid state poly(Gly) has been shown to adopt two regular conformations designated I and II. 

State I has an extended conformation like a β strand whilst state II has three resides per turn and is similar to poly(Pro).

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#Unit 1. Molecules and their Interaction Relevant to Biology

Beta sheets usually have their B strands either parallel or antiparallel

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#Unit 1. Molecules and their Interaction Relevant to Biology

β Sheets in proteins contain 2 to as many as 22 polypeptide strands, with an average of 6 strands. 

Each strand may contain up to 15 residues, the average being 6 residues.

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#Unit 1. Molecules and their Interaction Relevant to Biology

Repeat period is shorter for the parallel conformation (6.5 Å, vs. 7 Å for antiparallel)

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#Unit 1. Molecules and their Interaction Relevant to Biology

TLS Online TPP Program

#Id: 8477

#Unit 1. Molecules and their Interaction Relevant to Biology

Each single strand of the b-sheet structure can be pictured as a twofold helix, that is, a helix with two residues per turn.

The arrangement of successive amide planes has a pleated appearance due to the tetrahedral nature of the Ca atom.