Competition theory

TLS Online TPP Program

#Id: 5994

#Unit 3. Fundamental Processes

The rate of replication is 2000 bp/min, which is much slower than the 50,000 bp/min of bacterial replication fork movement, presumably because the chromosome is assembled into chromatin, not naked DNA.

TLS Online TPP Program

#Id: 5995

#Unit 3. Fundamental Processes

From the speed of replication, it is evident that a mammalian genome could be replicated in 1 hour if all replicons functioned simultaneously. S phase actually lasts for 6 hours in a typical somatic cell, though, which implies that no more than 15% of the replicons are likely to be active at any given moment.

TLS Online TPP Program

#Id: 5996

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 5997

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 5998

#Unit 3. Fundamental Processes

An ARS element consists of an A-T–rich region that contains discrete sites in which mutations affect origin function.

TLS Online TPP Program

#Id: 5999

#Unit 3. Fundamental Processes

A 14-bp “core” region, called the A domain, which contains an 11-bp consensus sequence consisting of A-T base pairs. This consensus sequence (sometimes called the ACS, for ARS)