Cushing syndrome Chronic excess of glucocorticoids (hypersecretion of ACTH from a pituitary adenoma)

TLS Online TPP Program

#Id: 10533

#Unit 4. Cell Communication and Cell Signaling

Pro-apoptotic members form channels in the mitochondrial outer membrane

Bax, Bak, Bok

TLS Online TPP Program

#Id: 10534

#Unit 4. Cell Communication and Cell Signaling

BH3-only proteins: Regulate activity of Bcl-2 and Bax/Bak proteins

Bim, Puma, Noxa, Bik, Bmf, Bad, Hrk, Bid

TLS Online TPP Program

#Id: 10535

#Unit 4. Cell Communication and Cell Signaling

Neurotrophins:

NGF 

Brain derived neurotrophic factor 

Neurotrophin-3 (NT-3)

TLS Online TPP Program

#Id: 10536

#Unit 4. Cell Communication and Cell Signaling

Neurotrophins binds with high affinity to the family of receptor tyrosine kinases called Trks-

NGF binds to TrkA

BDNF binds to TrkB

NT-3 binds to TrkC

TLS Online TPP Program

#Id: 10537

#Unit 4. Cell Communication and Cell Signaling

All neurotrophins also bind to a distinct type of receptor called p75NTR (NTR 5 neurotrophin receptor), but with lower affinity

TLS Online TPP Program

#Id: 10538

#Unit 4. Cell Communication and Cell Signaling

In healthy cells, the Bcl-2 or Bcl-xL blocking the ability of Bak or Bax to oligomerize and form pores in the outer mitochondrial membrane.