One metal ion reduces the affinity of the 3’-OH for its hydrogen. This generates a 3’O- that is primed for the nucleophilic attack of the a-phosphate of the incoming dNTP. 

TLS Online TPP Program

#Id: 6683

#Unit 3. Fundamental Processes

More than 90% of the genes expressed in mammals are alternatively spliced

TLS Online TPP Program

#Id: 8157

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 708

#Unit 3. Fundamental Processes

seqA is part of a negative regulatory circuit that prevents origins from being remethylated.

TLS Online TPP Program

#Id: 1178

#Unit 7. System Physiology – Animal

Axons of retinal ganglion cells 

Received and transduced information and carried to the CNS

TLS Online TPP Program

#Id: 5642

#Unit 7. System Physiology – Animal

Retinal is parallel to the surface of the membrane and is attached to a lysine residue at position 296 in the seventh TM domain.