The 5’–3’ exonuclease activity removes the RNA primer while simultaneously replacing it with a DNA sequence extended from the 3’–OH end of the next Okazaki fragment. 

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#Id: 4757

#Unit 5. Developmental Biology

Embryos from homozygous skn-1-deficient mothers lack both pharyngeal mesoderm & endoderm derivatives of EMS.

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#Id: 4758

#Unit 5. Developmental Biology

skn-1-deficient embryos make extra hypodermal (skin) & body wall tissue.

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#Id: 4759

#Unit 5. Developmental Biology

PAL-1 activity is needed for the normal development of the somatic (but not the germline) descendants of the P2 blastomere, specifies muscle production.

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#Id: 4760

#Unit 5. Developmental Biology

Embryos lacking PAL-1 have no somatic cell types derived from the C and D stem cells.

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#Id: 4761

#Unit 5. Developmental Biology

PAL-1 is regulated by the MEX-3 protein, an RNA binding protein that inhibit the translation of pal-1 mRNA.

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#Id: 4762

#Unit 5. Developmental Biology

In mex-3-deficient mutants, PAL-1 is seen in every blastomere.