#Id: 702

#Unit 3. Fundamental Processes

The replicase activity of DNA polymerase III was originally discovered by a conditional lethal mutation in the dnaE locus, which codes for the 130 kD, a subunit that possesses the DNA synthetic activity.

#Id: 703

#Unit 3. Fundamental Processes

The 3’–5’ exonucleolytic proofreading activity is found in E, coded by the dnaQ gene

#Id: 704

#Unit 3. Fundamental Processes

Mutations in dnaQ showed increased mutation frequency with by103-folds

#Id: 705

#Unit 3. Fundamental Processes

Proofreading typically decreases the error rate in replication from10-5 to 10-7 per base pair replicated.

#Id: 706

#Unit 3. Fundamental Processes

Repair Systems such as MMR reduces error rate of replication to 10-9 per base pair replicated

#Id: 707

#Unit 3. Fundamental Processes