RFC is a clamp loader that catalyzes the loading of PCNA onto DNA. It binds to the 3’ end of the DNA and uses ATP hydrolysis to open the ring of PCNA so that it can encircle the DNA.

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#Id: 6556

#Unit 7. System Physiology – Animal

Glucagon Secretion is increased by hypoglycaemia and decreased by a rise in plasma glucose

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#Id: 6557

#Unit 7. System Physiology – Animal

Human preproglucagon is a 179-amino-acid protein that is found in pancreatic A cells, in L cells in the lower GIT, and in the brain

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#Id: 6558

#Unit 7. System Physiology – Animal

In A cells, preproglucagon is processed primarily to glucagon and major proglucagon fragment (MPGF)

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#Id: 6559

#Unit 7. System Physiology – Animal

In L cells, preproglucagon is processed primarily to glicentin, & glucagon-like polypeptides 1 and 2. Some oxyntomodulin is also formed

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#Id: 6560

#Unit 7. System Physiology – Animal

In both A and L cells, residual glicentin-related polypeptide (GRPP) is left

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#Id: 6561

#Unit 7. System Physiology – Animal

GLP-1 is processed further by removal of its amino-terminal amino acid residues and the product, GLP-1 (7–36), is a potent stimulator of insulin secretion