RFC is a clamp loader that catalyzes the loading of PCNA onto DNA. It binds to the 3’ end of the DNA and uses ATP hydrolysis to open the ring of PCNA so that it can encircle the DNA.

TLS Online TPP Program

#Id: 1054

#Unit 5. Developmental Biology

Hox12 and Hox13 paralogues specify the autopod.

TLS Online TPP Program

#Id: 1055

#Unit 5. Developmental Biology

AER of the fin bud changes into an apical ectodermal fold that promotes fin ray development.

TLS Online TPP Program

#Id: 1056

#Unit 5. Developmental Biology

Limb field represents a “harmonious equipotent system” wherein a cell can be instructed to form any part of the limb.

TLS Online TPP Program

#Id: 1057

#Unit 5. Developmental Biology

The gene encoding Tbx5 is transcribed in limb fields of the forelimbs.

TLS Online TPP Program

#Id: 1058

#Unit 5. Developmental Biology

The genes encoding Islet1, Tbx4, and Pitx1 are expressed in presumptive hindlimbs.

TLS Online TPP Program

#Id: 1059

#Unit 5. Developmental Biology

Tbx stands for “T-box,” a specific DNA-binding domain.