RFC is a clamp loader that catalyzes the loading of PCNA onto DNA. It binds to the 3’ end of the DNA and uses ATP hydrolysis to open the ring of PCNA so that it can encircle the DNA.

TLS Online TPP Program

#Id: 480

#Unit 2. Cellular Organization

Interphase chromatin is a mass occupying a large part of the nuclear volume

TLS Online TPP Program

#Id: 481

#Unit 2. Cellular Organization

Mitotic chromosomes are highly organized and reproducible ultrastructure

TLS Online TPP Program

#Id: 482

#Unit 2. Cellular Organization

Interphase chromatin remain attached to nuclear wall proteins via matrix attachment regions (MARs) or matrix attachment DNA sequences

TLS Online TPP Program

#Id: 483

#Unit 2. Cellular Organization

Interphase chromosomes occupy chromosome territories in the nucleus and are not entangled with each other

TLS Online TPP Program

#Id: 484

#Unit 2. Cellular Organization

Heterochromatic regions, silenced genes, and gene-sparse regions of chromosomes are typically localized to the nuclear periphery.

TLS Online TPP Program

#Id: 485

#Unit 2. Cellular Organization

Active genes/euchromatin are often found at the borders of chromosome territories, and active genes from several chromosomes may cluster in inter-chromosomal territories that are enriched in transcription machinery.