TLS Online TPP Program

#Id: 6032


Synthesis of an Okazaki fragment displaces the RNA primer of the preceding fragment in the form of a “flap.”
the base of the flap is cleaved by the enzyme FEN1 (f lap endonuclease 1).  In this reaction, FEN1 functions as an endonuclease, but it also has a 5’–3’; exonuclease activity. In DNA repair reactions, FEN1 may cleave next to a displaced nucleotide and then use its exonuclease activity to remove adjacent material.

#Unit 3. Fundamental Processes #Eukaryotic DNA Replication #Part B Pointers