Longer mismatches (2 to 6 bp) recognized by heterodimer of MSH2 and MSH3.  Homologs of MutL, predominantly a heterodimer of MLH1 (MutL homolog) and PMS1 (post-meiotic segregation), bind to and stabilize the MSH complexes

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#Unit 8. Inheritance Biology

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#Unit 8. Inheritance Biology

TRANSLOCATIONS IN MEIOSIS The effect of a translocation on chromosome segregation in meiosis depends on the nature of the translocation.

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#Unit 8. Inheritance Biology

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#Unit 8. Inheritance Biology

It can be identified by G banding chromosome. 

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#Unit 8. Inheritance Biology

Philadelphia chromosome

Reciprocal translocation between the long arm of chromosome 22 and the tip of the long arm of chromosome 9. This translocation produces a shortened chromosome 22, called the Philadelphia chromosome.

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#Unit 8. Inheritance Biology

At the end of a normal chromosome 9 is a potential cancer-causing gene called c- ABL.   As a result of the translocation, part of the cABL gene is fused with the BCR gene from chromosome 22. The protein produced by this BCR–c-ABL fusion gene is much more active than the protein produced by the normal c- ABL gene.