In global genome repair (GG-NER), the XPC protein detects the damage and initiates the repair pathway. XPC can recognize damage anywhere in the genome. In mammals, XPC is a component of a lesion-sensing complex that also includes the proteins HR23B and centrin2.

TLS Online TPP Program

#Id: 9949

#Unit 4. Cell Communication and Cell Signaling

Resistance to leishmaniasis correlates well with the production of IFN-ϒ and the development of a TH1 response.

Strains of mice that are naturally resistant to Leishmania develop a TH1 response and produce IFN-ϒ upon infection. 

TLS Online TPP Program

#Id: 9950

#Unit 4. Cell Communication and Cell Signaling

Parasitic Worms (Helminths) Typically Generate Weak Immune Responses

TLS Online TPP Program

#Id: 9951

#Unit 4. Cell Communication and Cell Signaling

Natural immunity to helminth infections is Th2-type responses, including ILC2s, and IL-4 and IgE production.

TLS Online TPP Program

#Id: 9952

#Unit 4. Cell Communication and Cell Signaling

Immune Response Generated against Schistosoma mansoni

TLS Online TPP Program

#Id: 9953

#Unit 4. Cell Communication and Cell Signaling

Fungal disease

The barriers of innate immunity control most fungi.

Phagocytosis by neutrophils is a strong defense against most fungi

TLS Online TPP Program

#Id: 9954

#Unit 4. Cell Communication and Cell Signaling