TLS Online TPP Program

#Id: 5182

#Unit 7. System Physiology – Animal

During formation of a clot the initial event is constriction of the vessel and formation of a temporary hemostatic plug of platelets.

TLS Online TPP Program

#Id: 5183

#Unit 7. System Physiology – Animal

The vasoconstriction is due to serotonin, histamines & other vasoconstrictors liberated from platelets that adhere to the walls of the damaged vessels.

TLS Online TPP Program

#Id: 5184

#Unit 7. System Physiology – Animal

The loose aggregation of platelets in the temporary plug is bound together and converted into the definitive clot by fibrin.

TLS Online TPP Program

#Id: 5185

#Unit 7. System Physiology – Animal

Fibrin formation involves a cascade of enzymatic reactions and a series of numbered clotting factors.

TLS Online TPP Program

#Id: 5186

#Unit 7. System Physiology – Animal

The fundamental reaction is conversion of the soluble plasma protein fibrinogen to insoluble fibrin.

TLS Online TPP Program

#Id: 5187

#Unit 7. System Physiology – Animal

The fibrin is initially a loose mesh of interlacing strands. It is converted by the formation of covalent cross linkages to a dense, tight aggregate (stabilization).