Adenoviral vectors

Adenoviruses are large linear double-stranded DNA viruses. Their large size enables them to accept large inserts. 

TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 

expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods

TLS Online TPP Program

#Id: 9477

#Unit 4. Cell Communication and Cell Signaling

All SOCS proteins contains:

SH2 domain

SOCS box

TLS Online TPP Program

#Id: 9478

#Unit 4. Cell Communication and Cell Signaling

SOCS box, 

Recruits E3 ubiquitin ligases that polyubiquitinylate the receptor and the JAK kinase & marks the proteins for destruction by a proteasome

TLS Online TPP Program

#Id: 9479

#Unit 4. Cell Communication and Cell Signaling

SOCS-1, binds to the critical phosphotyrosine in the activation loop of an activated JAK2 kinase, inhibiting its catalytic activity

TLS Online TPP Program

#Id: 9480

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9481

#Unit 4. Cell Communication and Cell Signaling