Nonsense mutations release ribosomes within the RNA of a multigene operon, though, enabling rho to terminate transcription prematurely and prevent expression of distal genes in the transcription unit even though their open reading frames contained wild-type sequences.

TLS Online TPP Program

#Id: 9324

#Unit 4. Cell Communication and Cell Signaling

Rhodopsin kinase, a member of the GRK family of kinases catalyzes phosphorylation of activated rhodopsin

TLS Online TPP Program

#Id: 9325

#Unit 4. Cell Communication and Cell Signaling

Each opsin molecule has multiple principal serine and threonine phosphorylation sites on its cytosol-facing C-terminal segment.

TLS Online TPP Program

#Id: 9326

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9327

#Unit 4. Cell Communication and Cell Signaling

The binding of arrestin to rhodopsin speeds up the inactivation process.

TLS Online TPP Program

#Id: 9328

#Unit 4. Cell Communication and Cell Signaling

Arrestin binds tightly to rhodopsin only when rhodopsin kinase has phosphorylated a sufficient number of C-terminal serines and threonines.

TLS Online TPP Program

#Id: 9329

#Unit 4. Cell Communication and Cell Signaling

The entire process of rhodopsin phosphorylation and its inactivation by arrestin is fast completed within 50ms.