Nurturing Life Sciences
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#Unit 2. Cellular Organization
H3.3 is often referred to as a “replacement” histone.
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The H2A variants are the largest and most diverse family of core histone variants.
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H2AX is normally present in only 10%–15% of the nucleosomes in multicellular eukaryotes
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H2AX subtype is has a C-terminal tail that is distinct from the canonical H2A, characterized by a SQEL/Y motif at the end.
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SQEL/Y motif of H2AX is phosphorylated by ATM/ATR kinases, activated by DNA damage, is involved in DNA repair
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H2AX phosphorylated at the SQEL/Y motif is sometimes referred to as “gamma-H2AX,”