X-Linked Dominant Traits

X-linked dominant traits affect both males and females. 

Although they often appear more frequently in females than in males.

Affected males must have affected mothers (unless the males possess a new mutation), and they pass the trait to all their daughters.

Affected daughters must have either an affected mother or an affected father.

X-linked dominant traits do not skip generations.

TLS Online TPP Program

#Id: 426

#Unit 2. Cellular Organization

Heterochromatin generally maintains 10,000-fold compaction in both interphase and mitosis after 30 nm.

TLS Online TPP Program

#Id: 427

#Unit 2. Cellular Organization

Chromatin contains DNA, Histones, Nonhistone Proteins and RNA. RNA polymerase is a prominent nonhistone protein

TLS Online TPP Program

#Id: 428

#Unit 2. Cellular Organization

Individual nucleosomes can be obtained by treating chromatin with the endonuclease micrococcal nuclease (MNase), which cuts the DNA between nucleosomes, a region known as linker DNA.

TLS Online TPP Program

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#Unit 2. Cellular Organization

Mononucleosomes typically have 200 bp DNA. End-trimming reduces the length of DNA first to 165 bp and then generates core particles with 146 bp.

TLS Online TPP Program

#Id: 430

#Unit 2. Cellular Organization

Mnase digestion result on centrifugation and electrophoresis

TLS Online TPP Program

#Id: 431

#Unit 2. Cellular Organization

Core DNA has an invariant length of 146 bp the minimum length of DNA needed to form a stable monomeric nucleosome, and is relatively resistant to digestion by nucleases.