TLS Online TPP Program

#Id: 406

#Unit 2. Cellular Organization

In yeast, centromeric nucleosomes consist of Cse4, H4, and a nonhistone protein Scm3, in place of H2A-H2B dimers.

TLS Online TPP Program

#Id: 407

#Unit 2. Cellular Organization

In Drosophila, the centromeric chromatin appears to consist of “hemisomes” containing one copy each of CenH3, H4, H2A, and H2B.

TLS Online TPP Program

#Id: 408

#Unit 2. Cellular Organization

Histone H3.1 is replicative histone.

TLS Online TPP Program

#Id: 409

#Unit 2. Cellular Organization

H3.3 is expressed throughout the cell cycle, in contrast to most histones that are expressed during S phase during replication.

TLS Online TPP Program

#Id: 410

#Unit 2. Cellular Organization

H3.3 is available for assembly at any time in the cell cycle, and is incorporated at sites of active transcription, where nucleosomes become disrupted.

TLS Online TPP Program

#Id: 411

#Unit 2. Cellular Organization

H3.3 is often referred to as a “replacement” histone.