TLS Online TPP Program

#Id: 164

#Unit 5. Developmental Biology

The two major parts of the eye (lens and retina) co-construct each other, and the eye forms from reciprocal paracrine interactions.

TLS Online TPP Program

#Id: 165

#Unit 5. Developmental Biology

First inducers of the lens are foregut endoderm and cardiac mesoderm that underlie the lens-forming ectoderm during the early and mid gastrula stages.

TLS Online TPP Program

#Id: 166

#Unit 5. Developmental Biology

Foregut endoderm and cardiac mesoderm cause the synthesis of the Otx2 transcription factor in the head ectoderm during the late gastrula stage

TLS Online TPP Program

#Id: 167

#Unit 5. Developmental Biology

The anterior neural plate produce the next signals, that promotes the synthesis of the Pax6 transcription factor in the anterior ectoderm.

TLS Online TPP Program

#Id: 168

#Unit 5. Developmental Biology

Expression of Pax6 protein constitute the competence of the surface ectoderm to respond to the optic vesicle.

TLS Online TPP Program

#Id: 169

#Unit 5. Developmental Biology

The optic vesicle secrete two paracrine factors:

 BMP4

 FGF8