Type 1 diabetes (insulin-dependent diabetes mellitus) ] is due to insulin deficiency caused by autoimmune destruction of the B cells in the pancreatic islets

TLS Online TPP Program

#Id: 1696

#Unit 4. Cell Communication and Cell Signaling

RAG1 subunit and contains two aspartic acid residues and one glutamic acid residue (D600, D708, and E962, respectively). This active site “DDE motif” is found in many enzymes that cleave DNA

TLS Online TPP Program

#Id: 1697

#Unit 4. Cell Communication and Cell Signaling

ZnA and ZnB on RAG1 are regions of the proteins that form zinc fingers, elongated protein domains stabilized by the coordination of a Zn ion.

TLS Online TPP Program

#Id: 1698

#Unit 4. Cell Communication and Cell Signaling

The ZnA region of the protein assists in the initial RAG1 binding to active chromatin via its ability to interact with histone H3.

TLS Online TPP Program

#Id: 1699

#Unit 4. Cell Communication and Cell Signaling

Granulocytes

1. Neutrophils

2. Basophils

3. Mast cells

4. Eosinophils

TLS Online TPP Program

#Id: 1700

#Unit 4. Cell Communication and Cell Signaling

Granulocytes can be seen by FACS.

TLS Online TPP Program

#Id: 1701

#Unit 4. Cell Communication and Cell Signaling

Neutrophils constitute the majority (50% to 70%) of circulating leukocytes Eosinophils (1%–3%), Basophils (1%), or Mast cells (1%).