TLS Online TPP Program

#Id: 1558

#Unit 4. Cell Communication and Cell Signaling

Wnt proteins are essential for- 

Brain development

Limb patterning

Organogenesis

Formation of osteoblasts

TLS Online TPP Program

#Id: 1559

#Unit 4. Cell Communication and Cell Signaling

Wnt proteins are synthesized in the ER & modified by the addition of lipids (palmitic and palmitoleic acid).

 

TLS Online TPP Program

#Id: 1560

#Unit 4. Cell Communication and Cell Signaling

Lipid modifications of Wnt are catalyzed by the O-acetyltransferase Porcupine.

TLS Online TPP Program

#Id: 1561

#Unit 4. Cell Communication and Cell Signaling

Principal signaling receptor for Wnt proteins is Frizzled (Fz), which contains seven transmembrane α helices.

TLS Online TPP Program

#Id: 1562

#Unit 4. Cell Communication and Cell Signaling

Lipidated Wnt can bind to Frizzled receptor because lipids are essential for Wnt to bind to Frizzled.

TLS Online TPP Program

#Id: 1563

#Unit 4. Cell Communication and Cell Signaling

This is the example of post-translational modification by a lipid that mediates a ligand-receptor interaction.