Splice sites are directional in nature. 5’ splice site -the left, or donor, site and the 3’ splice site - right, or acceptor, site

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#Id: 6556

#Unit 7. System Physiology – Animal

Glucagon Secretion is increased by hypoglycaemia and decreased by a rise in plasma glucose

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#Id: 6557

#Unit 7. System Physiology – Animal

Human preproglucagon is a 179-amino-acid protein that is found in pancreatic A cells, in L cells in the lower GIT, and in the brain

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#Id: 6558

#Unit 7. System Physiology – Animal

In A cells, preproglucagon is processed primarily to glucagon and major proglucagon fragment (MPGF)

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#Id: 6559

#Unit 7. System Physiology – Animal

In L cells, preproglucagon is processed primarily to glicentin, & glucagon-like polypeptides 1 and 2. Some oxyntomodulin is also formed

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#Id: 6560

#Unit 7. System Physiology – Animal

In both A and L cells, residual glicentin-related polypeptide (GRPP) is left

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#Id: 6561

#Unit 7. System Physiology – Animal

GLP-1 is processed further by removal of its amino-terminal amino acid residues and the product, GLP-1 (7–36), is a potent stimulator of insulin secretion