Splice sites are directional in nature. 5’ splice site -the left, or donor, site and the 3’ splice site - right, or acceptor, site

TLS Online TPP Program

#Id: 7495

#Unit 4. Cell Communication and Cell Signaling

This recombinational event is catalyzed by a set of enzymes, many of which are also involved in nonhomologous end joining (NHEJ) DNA repair functions that occur in all cells.

TLS Online TPP Program

#Id: 7496

#Unit 4. Cell Communication and Cell Signaling

Only three of the proteins implicated in V(D)J recombination are unique to lymphocytes: RAG1, RAG2, and Terminal deoxynucleotidyl Transferase (TdT)

TLS Online TPP Program

#Id: 7497

#Unit 4. Cell Communication and Cell Signaling

Recombination between the D and a JH gene segment occur during pre-pro-B cell to the early pro-B-cell stage.

TLS Online TPP Program

#Id: 7498

#Unit 4. Cell Communication and Cell Signaling

Recombination between the VH and D-JH segments follows during the pro-B-cell stage.

TLS Online TPP Program

#Id: 7499

#Unit 4. Cell Communication and Cell Signaling

VpreB and λ5 (called a surrogate light chain), to form a pre-B-cell receptor.

TLS Online TPP Program

#Id: 7500

#Unit 4. Cell Communication and Cell Signaling

Light-chain recombination occurs at the small pre-B-cell stage of B-cell development.