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TLS Online TPP Program

#Id: 6678

Group II mitochondrial introns are excised by the same mechanism as nuclear pre-mRNAs via a lariat that is held together by a 2’–5’ bond.



#Unit 3. Fundamental Processes #Capping, Polyadenylation, Splicing and Alternative splicing #Part B Pointers
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TLS Online TPP Program

#Id: 1499

#Unit 4. Cell Communication and Cell Signaling

P53 turned on sets of large intergenic noncoding RNAs to mediate transcription repression; and miRNAs.
TLS Online TPP Program

#Id: 1500

#Unit 4. Cell Communication and Cell Signaling

p2I -IincRNA, mediates the repressive properties of p53 by binding to specific chromatin complexes.
TLS Online TPP Program

#Id: 1501

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.
 
TLS Online TPP Program

#Id: 1502

#Unit 4. Cell Communication and Cell Signaling

p53 amyloid aggregates,
No transport from cytoplasm to the nucleus
Escape proteasome degradation
TLS Online TPP Program

#Id: 1503

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 demonstrated by biophysical techniques:
X-ray diffraction 
Fourier transform infrared spectroscopy (FTIR)
TLS Online TPP Program

#Id: 3196

#Unit 4. Cell Communication and Cell Signaling

Mutations in three broad classes of genes play key roles in cancer induction: 

Proto-oncogenes genes
Tumor-suppressor genes
Genome maintenance genes