Group II mitochondrial introns are excised by the same mechanism as nuclear pre-mRNAs via a lariat that is held together by a 2’–5’ bond.

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#Unit 7. System Physiology – Animal

Thrombin is a serine protease that is formed from its circulating precursor, prothrombin, by the action of activated factor X.

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#Unit 7. System Physiology – Animal

The conversion of fibrinogen to fibrin is catalyzed by thrombin.

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#Unit 7. System Physiology – Animal

Stabilization of fibrin is catalyzed by activated factor XIII and Ca2

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#Unit 7. System Physiology – Animal

The extrinsic pathway is inhibited by a tissue factor pathway inhibitor that forms a quaternary structure with tissue thromboplastin (TPL), factor VIIa, and factor Xa.

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#Unit 7. System Physiology – Animal

Hemophilia A, is caused by factor VIII deficiency.

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#Id: 5203

#Unit 7. System Physiology – Animal

von Willebrand factor deficiency likewise causes a bleeding disorder (von Willebrand disease) by reducing platelet adhesion and by lowering plasma factor VIII