TLS Online TPP Program

#Id: 488

#Unit 2. Cellular Organization

(MARs) also called scaffold attachment regions (SARs), or S/MARs in case of metaphase chromosome as the same sequences appear to attach to the protein substructure in both metaphase and interphase cells.

TLS Online TPP Program

#Id: 489

#Unit 2. Cellular Organization

In interphase nuclei, this underlying proteinaceous structure changes its organization to occupy the entire nucleus; during interphase the structure is referred to as the matrix rather than the scaffold.

TLS Online TPP Program

#Id: 490

#Unit 2. Cellular Organization

S/MARs is a DNA sequence which binds to base structure called scaffold.

TLS Online TPP Program

#Id: 491

#Unit 2. Cellular Organization

If histones are depleted from a metaphase chromosome and viewed under a transmission electron microscope shows SCAFFOLD.

TLS Online TPP Program

#Id: 492

#Unit 2. Cellular Organization

The metaphase scaffold consists of a dense network of fibers. Threads of DNA emanate from the scaffold, apparently as loops of average length 30 to 90 kb.

TLS Online TPP Program

#Id: 493

#Unit 2. Cellular Organization

S/MARs are constitutive (continuously bound to the matrix or scaffold), or facultative and change their interactions with the matrix depending on cell type or other conditions.