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TLS Online TPP Program

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APOBEC3G (A3G)—is a potent inhibitor of infection by a range of retroviruses, including HIV. deaminates Cs to produce Us in that DNA strand, leading to hypermutation at levels the virus cannot accommodate, or even to destruction of the damaged strand by DNA glycosylase and apurinic apyrimidinic endonuclease

#Unit 3. Fundamental Processes #Capping, Polyadenylation, Splicing and Alternative splicing #Part B Pointers
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TLS Online TPP Program

#Id: 8323

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8324

#Unit 2. Cellular Organization

The rate of addition of monomers is given by
rate constant kon (M–1 sec–1 )
The rate of loss is given by koff (sec–1)

TLS Online TPP Program

#Id: 8325

#Unit 2. Cellular Organization

Critical concentration (Cc)
minimal concentration of monomers at which filaments form


TLS Online TPP Program

#Id: 8326

#Unit 2. Cellular Organization

The two ends of microfilament polymerize at different rates:
fast-growing end - plus end
slow-growing end - minus end

TLS Online TPP Program

#Id: 8327

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8328

#Unit 2. Cellular Organization

Hydrolysis of the bound nucleotide reduces the binding affinity of the subunit for neighbouring subunits and makes it more likely to dissociate from each end of the filament.
T form that adds to the filament and the D form that leaves.


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