The most well studied type of DE is the AU-rich element (ARE) AUUUA, found in the 3’ UTR of up to 8% of mammalian mRNAs

TLS Online TPP Program

#Id: 5548

#Unit 7. System Physiology – Animal

In the early distal tubule Approximately 5% of the filtered load of sodium chloride is reabsorbed through sodium-chloride co-transporter 

TLS Online TPP Program

#Id: 5549

#Unit 7. System Physiology – Animal

The thiazide diuretics, inhibit the sodium-chloride co-transporter

TLS Online TPP Program

#Id: 5550

#Unit 7. System Physiology – Animal

The second half of the distal tubule and the subsequent cortical collecting tubule have two distinct cell types:  principal cells and intercalated cells

TLS Online TPP Program

#Id: 5551

#Unit 7. System Physiology – Animal

The principal cells reabsorb sodium and water from the lumen and secrete potassium ions into the lumen

TLS Online TPP Program

#Id: 5552

#Unit 7. System Physiology – Animal

The principal cells are the primary sites of action of the potassium-sparing diuretics, including spironolactone, eplerenone, amiloride, and triamterene

TLS Online TPP Program

#Id: 5553

#Unit 7. System Physiology – Animal

Intercalated cells play a major role in acid-base regulation and constitute 30 to 40 percent of the cells in the collecting tubules and collecting ducts