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TLS Online TPP Program

#Id: 6771

nonstop-mediated decay rescues ribosomes that translate mRNAs that lack a stop codon. When an mRNA lacking a stop codon is translated, the ribosome translates through the poly-A tail This results 



#Unit 3. Fundamental Processes #mRNA stability, transport, CRISPR, miRNA & siRNA #Part B Pointers
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TLS Online TPP Program

#Id: 7488

#Unit 4. Cell Communication and Cell Signaling

Multiple gene segments exist at heavy (V, D, and J) and light-chain (V and J) loci.
TLS Online TPP Program

#Id: 7489

#Unit 4. Cell Communication and Cell Signaling

Junctional diversity- P and N nucleotides  addition 
TLS Online TPP Program

#Id: 7490

#Unit 4. Cell Communication and Cell Signaling

P nucleotide addition results when the DNA hairpin at the coding joint is cleaved asymmetrically.
TLS Online TPP Program

#Id: 7491

#Unit 4. Cell Communication and Cell Signaling

Non - templated N nucleotide addition in heavy chains results from TdT activity. 
TLS Online TPP Program

#Id: 7492

#Unit 4. Cell Communication and Cell Signaling

Exonuclease trimming sometimes occurs at the VDJ and VJ junctions, causing loss of nucleotides.
TLS Online TPP Program

#Id: 7493

#Unit 4. Cell Communication and Cell Signaling

Combinatorial diversity: The same heavy chain can combine with different light chain