TLS Online TPP Program

#Id: 10461

#Unit 4. Cell Communication and Cell Signaling

In Burkitt’s lymphoma cells, 

MYC is translocated close to an antibody gene, leading to overproduction of MYC

TLS Online TPP Program

#Id: 10462

#Unit 4. Cell Communication and Cell Signaling

MYC gene encodes a basic helix-loop-helix protein

include MAD, MAX, and MNT

TLS Online TPP Program

#Id: 10463

#Unit 4. Cell Communication and Cell Signaling

MYC-MAX dimers regulate genes that control proliferation, such as cyclins.

TLS Online TPP Program

#Id: 10464

#Unit 4. Cell Communication and Cell Signaling

MAD and MNT work with the SIN3 co-repressor protein to bring in histone deacetylases that help to block transcription

TLS Online TPP Program

#Id: 10465

#Unit 4. Cell Communication and Cell Signaling

A classic inherited cancer syndrome is retinoblastoma, which is caused by loss of function of RB.

TLS Online TPP Program

#Id: 10466

#Unit 4. Cell Communication and Cell Signaling

Children with hereditary (familial) retinoblastoma inherit one defective copy of the RB gene 

(sometimes seen as a small deletion on one of the two copies of chromosome 13)