Rap1 recruits Sir4 on acetylated histones, then recruits both its binding partner Sir3 and the HDAC Sir2. 

Sir3 and Sir4 then interact directly with histones H3 and H4. Once Sir3 and Sir4 have bound to histones H3 and H4, 

Sir2 deacetylates histones

Sir2-dependent deacetylation represses transcription.

TLS Online TPP Program

#Id: 1276

#Unit 7. System Physiology – Animal

Cortisol induces the synthesis of lipocortin, an inhibitor of the enzyme PLA2. 

TLS Online TPP Program

#Id: 1108

#Unit 2. Cellular Organization

E1’s ion-binding sites are exposed to the cytoplasm, and it has high affinity for Na+ but low affinity for K+

TLS Online TPP Program

#Id: 2909

#Unit 3. Fundamental Processes

he prepriming complex generates a protein aggregate of 480 kD, which corresponds to a sphere of radius 6 nm

TLS Online TPP Program

#Id: 6476

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 10430

#Unit 4. Cell Communication and Cell Signaling

SWI/SNF normally plays a role in repressing the E2F genes, inhibiting progression through the cell cycle.