In human cells, the centromere- specific protein CENP-B is required to initiate modifications of histone H3 (deacetylation of K9 and K14, followed by methylation of K9) that trigger an association with HP1 that leads to the formation of heterochromatin in the region.
#Unit 3. Fundamental Processes#Chromatin Remodelling & Epigenetics#Part B Pointers