There are two de novo methyltransferases (Dnmt3A and Dnmt3B) in the mouse; they have different target sites, and both are essential for development.

TLS Online TPP Program

#Id: 9651

#Unit 4. Cell Communication and Cell Signaling

Phosphorylation by MEK at Y-185 and T-183 in activation loop of MAP kinase leads to a marked conformational change & promotes MAP kinase activation and dimerization.

TLS Online TPP Program

#Id: 9652

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 9653

#Unit 4. Cell Communication and Cell Signaling

Activated dimeric MAP kinase induces transcription of the c-fos gene by directly activating TCF, and indirectly activating SRF.

TLS Online TPP Program

#Id: 9654

#Unit 4. Cell Communication and Cell Signaling

Feedback regulation by MAP Kinase

activated MAP kinase phosphorylates the HER1 on a threonine residue near the juxtamembrane domain. 

TLS Online TPP Program

#Id: 9655

#Unit 4. Cell Communication and Cell Signaling

Feedback regulation by MAP Kinase

Phosphorylation of threonine residue in HER1 decreases the ability of the receptor kinase to become fully active.

TLS Online TPP Program

#Id: 9656

#Unit 4. Cell Communication and Cell Signaling

Feedback regulation by MAP Kinase

Active MAP kinase phosphorylates Raf on multiple sites, reducing its association with Ras.